Read the full guide: Azelaic acid and tretinoin: how to layer them
How to use them
Use them in the same routine at night. Apply Azelaic Acid first, then Tretinoin, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2Azelaic Acid10% – 20%, wait about 1 minute
- 3Tretinoin0.025% – 0.1% (prescription)
- 4Moisturiserseal everything in
What Azelaic Acid does
A multitasker that treats acne, rosacea redness and pigmentation at the same time. It is widely considered safe in pregnancy, so it is a common swap for retinoids.
- Typical strength
- 10% – 20%
- When
- AM/PM
- Irritation
- Best for
- Sensitive, Oily, Combination And Normal skin
Everything that pairs with Azelaic Acid →
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
Trying to choose one? Read Azelaic Acid vs Tretinoin: which is better for your skin.
Frequently asked questions
Can I use Azelaic Acid and Tretinoin together?
Yes, it is safe. Dermatologists often combine them, for acne with dark marks or for melasma, because they work differently: azelaic acid calms inflammation, slows pigment production and unclogs pores, while tretinoin speeds up cell turnover. The catch is irritation, since both can sting and dry skin in the first weeks. Many people use azelaic acid in the morning and tretinoin at night, or alternate nights. Tretinoin is a prescription medicine, so follow your doctor's plan.
Which goes first, Azelaic Acid or Tretinoin?
Apply Azelaic Acid first, then Tretinoin. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Azelaic Acid in the morning or at night?
Azelaic Acid: works morning or night. Apply once or twice daily. A mild tingle in the first week is normal.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Is Azelaic Acid with Tretinoin safe during pregnancy?
Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.