How to use them
Use them in the same routine at night. Apply Polyglutamic Acid first, then Tretinoin, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2Polyglutamic Acid1% – 3%, wait about 1 minute
- 3Tretinoin0.025% – 0.1% (prescription)
- 4Moisturiserseal everything in
What Polyglutamic Acid does
A bigger-molecule humectant that forms a moisture-holding film on the skin. It is often paired with hyaluronic acid for plump, long-lasting hydration.
- Typical strength
- 1% – 3%
- When
- AM/PM
- Irritation
- Best for
- Dry, Normal, Combination, Sensitive And Oily skin
Everything that pairs with Polyglutamic Acid →
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
Frequently asked questions
Can I use Polyglutamic Acid and Tretinoin together?
Yes, and they work even better together. Polyglutamic Acid cushions Tretinoin: it hydrates and supports the barrier while the active does its work. That means less irritation and better results.
Which goes first, Polyglutamic Acid or Tretinoin?
Apply Polyglutamic Acid first, then Tretinoin. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Polyglutamic Acid in the morning or at night?
Polyglutamic Acid: works morning or night. Apply after toner and before moisturiser, morning or night.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Is Polyglutamic Acid with Tretinoin safe during pregnancy?
Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.