How to use them
Alternate nights, for example Salicylic Acid on Monday, Wednesday and Friday and Tretinoin on Tuesday and Thursday, with a plain moisturiser night in between if your skin feels sensitive. If your skin is resilient and already used to both, you can try layering them: apply Salicylic Acid first, wait a few minutes, then apply Tretinoin.
- 1CleanseGentle cleanser, pat dry
- AMSalicylic Acid (day 1)then moisturiser and SPF 50
- PMTretinoin (day 2)then moisturiser
What Salicylic Acid does
An oil-soluble beta-hydroxy acid that gets inside pores to dissolve the sebum and dead skin behind blackheads, whiteheads and breakouts. It is the go-to for oily, acne-prone skin.
- Typical strength
- 0.5% – 2%
- When
- AM/PM
- Irritation
- Best for
- Oily And Combination skin
Everything that pairs with Salicylic Acid →
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
Trying to choose one? Read Salicylic Acid vs Tretinoin: which is better for your skin.
Frequently asked questions
Can I use Salicylic Acid and Tretinoin together?
Yes, but not at the same time. Both Salicylic Acid and Tretinoin speed up cell turnover. Used in the same routine they commonly cause redness, peeling and a damaged barrier, especially in India's heat and humidity. Alternate nights instead.
Which goes first, Salicylic Acid or Tretinoin?
Apply Salicylic Acid first, then Tretinoin. The general rule is thinnest to thickest texture, and lowest pH first. For this pair, though, it is better not to layer them in the same routine at all.
Should I use Salicylic Acid in the morning or at night?
Salicylic Acid: works morning or night. Use as a cleanser daily or a leave-on 2% serum 3–4 times a week. It can dry out skin, so moisturise well.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Is Salicylic Acid with Tretinoin safe during pregnancy?
Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.