How to use them
Use them in the same routine morning or night. Apply PDRN first, then Azelaic Acid, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2PDRNvaries (often with PN/polynucleotides blends), wait about 1 minute
- 3Azelaic Acid10% – 20%
- 4Moisturiserseal everything in
What Azelaic Acid does
A multitasker that treats acne, rosacea redness and pigmentation at the same time. It is widely considered safe in pregnancy, so it is a common swap for retinoids.
- Typical strength
- 10% – 20%
- When
- AM/PM
- Irritation
- Best for
- Sensitive, Oily, Combination And Normal skin
Everything that pairs with Azelaic Acid →
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
Frequently asked questions
Can I use Azelaic Acid and PDRN together?
Yes, it is safe. There is no known chemical conflict between Azelaic Acid and PDRN, and neither makes the other less effective.
Which goes first, Azelaic Acid or PDRN?
Apply PDRN first, then Azelaic Acid. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Azelaic Acid in the morning or at night?
Azelaic Acid: works morning or night. Apply once or twice daily. A mild tingle in the first week is normal.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Is Azelaic Acid with PDRN safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN. Check with your doctor.