How to use them
Alternate nights, for example Benzoyl Peroxide on Monday, Wednesday and Friday and PDRN on Tuesday and Thursday, with a plain moisturiser night in between if your skin feels sensitive. If your skin is resilient and already used to both, you can try layering them: apply Benzoyl Peroxide first, wait a few minutes, then apply PDRN.
- 1CleanseGentle cleanser, pat dry
- AMBenzoyl Peroxide (day 1)then moisturiser and SPF 50
- PMPDRN (day 2)then moisturiser
What Benzoyl Peroxide does
It kills acne-causing bacteria (C. acnes) by releasing oxygen into the pore. It works fast on inflamed pimples, but it is drying and can bleach towels and pillowcases.
- Typical strength
- 2.5% – 5%
- When
- AM/PM
- Irritation
- Best for
- Oily And Combination skin
Everything that pairs with Benzoyl Peroxide →
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
Frequently asked questions
Can I use Benzoyl Peroxide and PDRN together?
Yes, but not at the same time. Benzoyl peroxide is an oxidiser and may degrade delicate peptides. Keep them in different routines.
Which goes first, Benzoyl Peroxide or PDRN?
Apply Benzoyl Peroxide first, then PDRN. The general rule is thinnest to thickest texture, and lowest pH first. For this pair, though, it is better not to layer them in the same routine at all.
Should I use Benzoyl Peroxide in the morning or at night?
Benzoyl Peroxide: works morning or night. 2.5% works about as well as 10% and irritates less. Use as a short-contact wash or a spot treatment, and keep it away from fabrics.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Is Benzoyl Peroxide with PDRN safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for Benzoyl Peroxide and PDRN. Check with your doctor.