How to use them
Use them in the same routine morning or night. Apply Hyaluronic Acid first, then PDRN, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2Hyaluronic Acid0.1% – 2%, wait about 1 minute
- 3PDRNvaries (often with PN/polynucleotides blends)
- 4Moisturiserseal everything in
What Hyaluronic Acid does
A humectant that holds many times its weight in water, plumping skin and smoothing dehydration lines. It pairs well with almost everything and cushions harsher actives.
- Typical strength
- 0.1% – 2%
- When
- AM/PM
- Irritation
- Best for
- Dry, Normal, Oily, Combination And Sensitive skin
Everything that pairs with Hyaluronic Acid →
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
Frequently asked questions
Can I use Hyaluronic Acid and PDRN together?
Yes, it is safe. There is no known chemical conflict between Hyaluronic Acid and PDRN, and neither makes the other less effective. They share a goal (hydration and barrier), so together they reinforce each other.
Which goes first, Hyaluronic Acid or PDRN?
Apply Hyaluronic Acid first, then PDRN. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Hyaluronic Acid in the morning or at night?
Hyaluronic Acid: works morning or night. Apply on slightly damp skin and seal with a moisturiser. In very dry air, skipping the seal can leave skin tighter.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Is Hyaluronic Acid with PDRN safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN. Check with your doctor.