How to use them
Alternate nights, for example Mandelic Acid on Monday, Wednesday and Friday and PDRN on Tuesday and Thursday, with a plain moisturiser night in between if your skin feels sensitive. If your skin is resilient and already used to both, you can try layering them: apply Mandelic Acid first, wait a few minutes, then apply PDRN.
- 1CleanseGentle cleanser, pat dry
- AMMandelic Acid (day 1)then moisturiser and SPF 50
- PMPDRN (day 2)then moisturiser
What Mandelic Acid does
The largest, slowest AHA. Dermatologists often pick it for melanin-rich Indian skin tones because it treats acne and pigmentation with a lower risk of post-inflammatory darkening.
- Typical strength
- 5% – 10%
- When
- PM
- Irritation
- Best for
- Sensitive, Oily And Combination skin
Everything that pairs with Mandelic Acid →
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
Frequently asked questions
Can I use Mandelic Acid and PDRN together?
Yes, but not at the same time. Low-pH acids can break down peptides, and with copper they can also irritate. Use the acid at one time of day and the peptide at the other, or on alternate nights.
Which goes first, Mandelic Acid or PDRN?
Apply Mandelic Acid first, then PDRN. The general rule is thinnest to thickest texture, and lowest pH first. For this pair, though, it is better not to layer them in the same routine at all.
Should I use Mandelic Acid in the morning or at night?
Mandelic Acid: best at night. Use 3–4 nights a week. It is mild enough that many people can use it more often than other acids.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Is Mandelic Acid with PDRN safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN. Check with your doctor.