How to use them
Use them in the same routine at night. Apply Panthenol first, then Tretinoin, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2Panthenol1% – 5%, wait about 1 minute
- 3Tretinoin0.025% – 0.1% (prescription)
- 4Moisturiserseal everything in
What Panthenol does
Pro-vitamin B5. It draws in moisture, calms redness and speeds up barrier repair. It shows up in "recovery" creams for good reason.
- Typical strength
- 1% – 5%
- When
- AM/PM
- Irritation
- Best for
- Sensitive, Dry, Normal, Combination And Oily skin
Everything that pairs with Panthenol →
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
Frequently asked questions
Can I use Panthenol and Tretinoin together?
Yes, and they work even better together. Panthenol cushions Tretinoin: it hydrates and supports the barrier while the active does its work. That means less irritation and better results.
Which goes first, Panthenol or Tretinoin?
Apply Panthenol first, then Tretinoin. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Panthenol in the morning or at night?
Panthenol: works morning or night. Use daily. It is especially useful after over-exfoliation or sunburn.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Is Panthenol with Tretinoin safe during pregnancy?
Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.