How to use them
Use them in the same routine at night. Apply Tretinoin first, then Squalane, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2Tretinoin0.025% – 0.1% (prescription), wait about 1 minute
- 3Squalaneup to 100%
- 4Moisturiserseal everything in
What Squalane does
A lightweight, stable oil that mimics your skin's own sebum. It softens and seals in moisture without clogging pores, so even oily skin usually tolerates it.
- Typical strength
- up to 100%
- When
- AM/PM
- Irritation
- Best for
- Dry, Normal, Combination, Sensitive And Oily skin
Everything that pairs with Squalane →
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
Frequently asked questions
Can I use Squalane and Tretinoin together?
Yes, and they work even better together. Squalane cushions Tretinoin: it hydrates and supports the barrier while the active does its work. That means less irritation and better results.
Which goes first, Squalane or Tretinoin?
Apply Tretinoin first, then Squalane. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Squalane in the morning or at night?
Squalane: works morning or night. Press 2–3 drops in as the last step at night, or mix a drop into your moisturiser.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Is Squalane with Tretinoin safe during pregnancy?
Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.