Glutathione vs Hydroquinone
Both target pigmentation. Here's how they differ, and whether you should pick one or use both.
| Glutathione | Hydroquinone | |
|---|---|---|
| Main job | Pigmentation, dullness and antioxidant | Pigmentation |
| Typical strength | 1% – 2% | 2% – 4% (prescription in India) |
| Best time | AM/PM | PM |
| Irritation | ||
| Best for | Normal, Oily, Combination, Dry And Sensitive | Normal, Oily And Combination |
| Pregnancy | Ask | Avoid |
| Price in India | ₹500 – ₹1,800 | ₹150 – ₹600 |
The verdict
For pigmentation, Hydroquinone is the stronger option, while Glutathione is gentler and better suited to sensitive or beginner skin.
Using both? Safe to mix There is no known chemical conflict between Glutathione and Hydroquinone, and neither makes the other less effective. They share a goal (pigmentation), so together they reinforce each other. How to layer them →
Glutathione in short
A popular "glow" antioxidant in India. Topically it has some evidence for mild brightening, but it is a large, unstable molecule. Expect modest results compared with vitamin C, arbutin or niacinamide.
Hydroquinone in short
The strongest topical depigmenting agent, used for melasma and stubborn dark spots. It blocks melanin production, but it must be used in short, supervised courses: long-term use can cause irritation and, rarely, ochronosis (blue-black darkening).
Not sure which fits your skin?
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