How to use them
Use them in the same routine at night. Apply Glutathione first, then Hydroquinone, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2Glutathione1% – 2%, wait about 1 minute
- 3Hydroquinone2% – 4% (prescription in India)
- 4Moisturiserseal everything in
What Glutathione does
A popular "glow" antioxidant in India. Topically it has some evidence for mild brightening, but it is a large, unstable molecule. Expect modest results compared with vitamin C, arbutin or niacinamide.
- Typical strength
- 1% – 2%
- When
- AM/PM
- Irritation
- Best for
- Normal, Oily, Combination, Dry And Sensitive skin
Everything that pairs with Glutathione →
What Hydroquinone does
The strongest topical depigmenting agent, used for melasma and stubborn dark spots. It blocks melanin production, but it must be used in short, supervised courses: long-term use can cause irritation and, rarely, ochronosis (blue-black darkening).
- Typical strength
- 2% – 4% (prescription in India)
- When
- PM
- Irritation
- Best for
- Normal, Oily And Combination skin
Everything that pairs with Hydroquinone →
Trying to choose one? Read Glutathione vs Hydroquinone: which is better for your skin.
Frequently asked questions
Can I use Glutathione and Hydroquinone together?
Yes, it is safe. There is no known chemical conflict between Glutathione and Hydroquinone, and neither makes the other less effective. They share a goal (pigmentation), so together they reinforce each other.
Which goes first, Glutathione or Hydroquinone?
Apply Glutathione first, then Hydroquinone. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Glutathione in the morning or at night?
Glutathione: works morning or night. Use daily as part of a brightening routine, always with sunscreen. Glutathione injections and drips for skin whitening are not approved for that use and carry real risks.
Should I use Hydroquinone in the morning or at night?
Hydroquinone: best at night. Use only under a dermatologist's guidance, typically nightly on the dark patches for up to 3 months, then take a break. Strict daily sunscreen is required or results reverse.
Is Glutathione with Hydroquinone safe during pregnancy?
Hydroquinone is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.