How to use them
Use them in the same routine morning or night. Apply PDRN first, then Ceramides, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2PDRNvaries (often with PN/polynucleotides blends), wait about 1 minute
- 3Ceramidesvaries
- 4Moisturiserseal everything in
What Ceramides does
Lipids that make up about half of your skin barrier. Topping them up reduces water loss, stinging and flakiness, which makes ceramides the best friend of anyone using retinoids or acids.
- Typical strength
- varies
- When
- AM/PM
- Irritation
- Best for
- Dry, Sensitive, Normal, Combination And Oily skin
Everything that pairs with Ceramides →
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
Frequently asked questions
Can I use Ceramides and PDRN together?
Yes, it is safe. There is no known chemical conflict between Ceramides and PDRN, and neither makes the other less effective. They share a goal (barrier and hydration), so together they reinforce each other.
Which goes first, Ceramides or PDRN?
Apply PDRN first, then Ceramides. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Ceramides in the morning or at night?
Ceramides: works morning or night. Use as your moisturiser step, morning and night. On nights with actives, you can buffer by applying a ceramide cream first.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Is Ceramides with PDRN safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN. Check with your doctor.