How to use them
Alternate nights, for example Glycolic Acid on Monday, Wednesday and Friday and Tretinoin on Tuesday and Thursday, with a plain moisturiser night in between if your skin feels sensitive. If your skin is resilient and already used to both, you can try layering them: apply Glycolic Acid first, wait a few minutes, then apply Tretinoin.
- 1CleanseGentle cleanser, pat dry
- AMGlycolic Acid (day 1)then moisturiser and SPF 50
- PMTretinoin (day 2)then moisturiser
What Glycolic Acid does
The smallest alpha-hydroxy acid, so it penetrates deepest. It dissolves the bonds between dead skin cells for smoother, brighter skin and fades marks, but it is the AHA most likely to sting.
- Typical strength
- 5% – 10%
- When
- PM
- Irritation
- Best for
- Normal, Oily And Combination skin
Everything that pairs with Glycolic Acid →
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
Trying to choose one? Read Glycolic Acid vs Tretinoin: which is better for your skin.
Frequently asked questions
Can I use Glycolic Acid and Tretinoin together?
Yes, but not at the same time. Both Glycolic Acid and Tretinoin speed up cell turnover. Used in the same routine they commonly cause redness, peeling and a damaged barrier, especially in India's heat and humidity. Alternate nights instead.
Which goes first, Glycolic Acid or Tretinoin?
Apply Glycolic Acid first, then Tretinoin. The general rule is thinnest to thickest texture, and lowest pH first. For this pair, though, it is better not to layer them in the same routine at all.
Should I use Glycolic Acid in the morning or at night?
Glycolic Acid: best at night. Use 2–3 nights a week after cleansing. Skip it on nights you use retinoids. Sunscreen is non-negotiable because AHAs raise sun sensitivity.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Is Glycolic Acid with Tretinoin safe during pregnancy?
Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.