How to use them
Use them in the same routine at night. Apply Niacinamide first, then Tretinoin, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2Niacinamide2% – 10%, wait about 1 minute
- 3Tretinoin0.025% – 0.1% (prescription)
- 4Moisturiserseal everything in
What Niacinamide does
An all-rounder that controls oil, strengthens the skin barrier, reduces redness and evens out tone. It gets along with almost every other active, which is why it is in so many routines.
- Typical strength
- 2% – 10%
- When
- AM/PM
- Irritation
- Best for
- Oily, Combination, Normal, Sensitive And Dry skin
Everything that pairs with Niacinamide →
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
Trying to choose one? Read Niacinamide vs Tretinoin: which is better for your skin.
Frequently asked questions
Can I use Niacinamide and Tretinoin together?
Yes, it is safe. There is no known chemical conflict between Niacinamide and Tretinoin, and neither makes the other less effective. They share a goal (pigmentation and acne), so together they reinforce each other.
Which goes first, Niacinamide or Tretinoin?
Apply Niacinamide first, then Tretinoin. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Niacinamide in the morning or at night?
Niacinamide: works morning or night. Use morning, night or both, after water-based serums. 4–5% is enough for most people. Very high percentages can cause flushing on sensitive skin.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Is Niacinamide with Tretinoin safe during pregnancy?
Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.