How to use them
Use them in the same routine morning or night. Apply PDRN first, then Panthenol, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2PDRNvaries (often with PN/polynucleotides blends), wait about 1 minute
- 3Panthenol1% – 5%
- 4Moisturiserseal everything in
What Panthenol does
Pro-vitamin B5. It draws in moisture, calms redness and speeds up barrier repair. It shows up in "recovery" creams for good reason.
- Typical strength
- 1% – 5%
- When
- AM/PM
- Irritation
- Best for
- Sensitive, Dry, Normal, Combination And Oily skin
Everything that pairs with Panthenol →
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
Frequently asked questions
Can I use Panthenol and PDRN together?
Yes, it is safe. There is no known chemical conflict between Panthenol and PDRN, and neither makes the other less effective. They share a goal (barrier and hydration), so together they reinforce each other.
Which goes first, Panthenol or PDRN?
Apply PDRN first, then Panthenol. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Panthenol in the morning or at night?
Panthenol: works morning or night. Use daily. It is especially useful after over-exfoliation or sunburn.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Is Panthenol with PDRN safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN. Check with your doctor.