How to use them
Choose one retinoid and use it 2–4 nights a week. Fill the other nights with hydrating and barrier-repair products.
- 1CleanseGentle cleanser, pat dry
- AMRetinol (day 1)then moisturiser and SPF 50
- PMTretinoin (day 2)then moisturiser
What Retinol does
The most studied over-the-counter anti-ageing active. Retinol speeds up cell turnover, softens fine lines, fades marks and keeps pores clear, but it can cause dryness, peeling and sun sensitivity while your skin adjusts.
- Typical strength
- 0.1% – 1%
- When
- PM
- Irritation
- Best for
- Normal, Oily And Combination skin
Everything that pairs with Retinol →
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
Trying to choose one? Read Retinol vs Tretinoin: which is better for your skin.
Frequently asked questions
Can I use Retinol and Tretinoin together?
No, keep them apart. Retinol and Tretinoin are both retinoids. Doubling up does not double results. It just doubles the dryness, peeling and irritation. Pick one.
Which goes first, Retinol or Tretinoin?
Apply Retinol first, then Tretinoin. The general rule is thinnest to thickest texture, and lowest pH first. For this pair, though, it is better not to layer them in the same routine at all.
Should I use Retinol in the morning or at night?
Retinol: best at night. Start 2–3 nights a week on dry skin, a pea-sized amount for the whole face, then build up. Always wear sunscreen the next morning.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Is Retinol with Tretinoin safe during pregnancy?
Retinol and Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.