Glycolic Acid vs PDRN
Both target aging. Here's how they differ, and whether you should pick one or use both.
| Glycolic Acid | PDRN | |
|---|---|---|
| Main job | Texture, dullness, pigmentation and aging | Aging, barrier and hydration |
| Typical strength | 5% – 10% | varies (often with PN/polynucleotides blends) |
| Best time | PM | AM/PM |
| Irritation | ||
| Best for | Normal, Oily And Combination | Normal, Dry, Sensitive And Combination |
| Pregnancy | Safe | Ask |
| Price in India | ₹400 – ₹2,000 | ₹1,200 – ₹4,000 |
The verdict
For aging, Glycolic Acid is the stronger option, while PDRN is gentler and better suited to sensitive or beginner skin.
Using both? Use with caution Low-pH acids can break down peptides, and with copper they can also irritate. Use the acid at one time of day and the peptide at the other, or on alternate nights. How to layer them →
Glycolic Acid in short
The smallest alpha-hydroxy acid, so it penetrates deepest. It dissolves the bonds between dead skin cells for smoother, brighter skin and fades marks, but it is the AHA most likely to sting.
PDRN in short
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
Not sure which fits your skin?
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