How to use them
Use them in the same routine morning or night. Apply PDRN first, then Bakuchiol, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2PDRNvaries (often with PN/polynucleotides blends), wait about 1 minute
- 3Bakuchiol0.5% – 2%
- 4Moisturiserseal everything in
What Bakuchiol does
A plant extract (from babchi seeds) that works like retinol in small studies, with far less dryness and no sun sensitivity. It is milder and slower than a true retinoid.
- Typical strength
- 0.5% – 2%
- When
- AM/PM
- Irritation
- Best for
- Sensitive, Dry And Normal skin
Everything that pairs with Bakuchiol →
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
Trying to choose one? Read Bakuchiol vs PDRN: which is better for your skin.
Frequently asked questions
Can I use Bakuchiol and PDRN together?
Yes, it is safe. There is no known chemical conflict between Bakuchiol and PDRN, and neither makes the other less effective. They share a goal (aging), so together they reinforce each other.
Which goes first, Bakuchiol or PDRN?
Apply PDRN first, then Bakuchiol. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Bakuchiol in the morning or at night?
Bakuchiol: works morning or night. Use twice daily. It is stable in sunlight, so a morning application is fine.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Is Bakuchiol with PDRN safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for Bakuchiol and PDRN. Check with your doctor.