How to use them
Alternate nights, for example Copper Peptides on Monday, Wednesday and Friday and Tretinoin on Tuesday and Thursday, with a plain moisturiser night in between if your skin feels sensitive. If your skin is resilient and already used to both, you can try layering them: apply Copper Peptides first, wait a few minutes, then apply Tretinoin.
- 1CleanseGentle cleanser, pat dry
- AMCopper Peptides (day 1)then moisturiser and SPF 50
- PMTretinoin (day 2)then moisturiser
What Copper Peptides does
A peptide bound to copper that supports wound-healing, firmness and barrier repair. Copper is reactive, so it does not play well with strong acids or pure vitamin C.
- Typical strength
- 0.1% – 1%
- When
- PM
- Irritation
- Best for
- Normal, Dry And Combination skin
Everything that pairs with Copper Peptides →
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
Trying to choose one? Read Copper Peptides vs Tretinoin: which is better for your skin.
Frequently asked questions
Can I use Copper Peptides and Tretinoin together?
Yes, but not at the same time. There is no dangerous reaction, but both are potent and copper peptides are thought to work best on their own. Most people use them on alternate nights.
Which goes first, Copper Peptides or Tretinoin?
Apply Copper Peptides first, then Tretinoin. The general rule is thinnest to thickest texture, and lowest pH first. For this pair, though, it is better not to layer them in the same routine at all.
Should I use Copper Peptides in the morning or at night?
Copper Peptides: best at night. Use at night on nights without acids or vitamin C. A thin layer is enough.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Is Copper Peptides with Tretinoin safe during pregnancy?
Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.