How to use them
Use them in the same routine at night. Apply Hydroquinone first, then Licorice Extract, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2Hydroquinone2% – 4% (prescription in India), wait about 1 minute
- 3Licorice Extractvaries (glabridin ~0.5%)
- 4Moisturiserseal everything in
What Hydroquinone does
The strongest topical depigmenting agent, used for melasma and stubborn dark spots. It blocks melanin production, but it must be used in short, supervised courses: long-term use can cause irritation and, rarely, ochronosis (blue-black darkening).
- Typical strength
- 2% – 4% (prescription in India)
- When
- PM
- Irritation
- Best for
- Normal, Oily And Combination skin
Everything that pairs with Hydroquinone →
What Licorice Extract does
Licorice root (mulethi) contains glabridin, which gently inhibits pigment production, and glycyrrhizinates, which calm redness. It is a mild brightener suited to sensitive skin.
- Typical strength
- varies (glabridin ~0.5%)
- When
- AM/PM
- Irritation
- Best for
- Sensitive, Normal, Combination, Dry And Oily skin
Everything that pairs with Licorice Extract →
Trying to choose one? Read Hydroquinone vs Licorice Extract: which is better for your skin.
Frequently asked questions
Can I use Hydroquinone and Licorice Extract together?
Yes, it is safe. There is no known chemical conflict between Hydroquinone and Licorice Extract, and neither makes the other less effective. They share a goal (pigmentation), so together they reinforce each other.
Which goes first, Hydroquinone or Licorice Extract?
Apply Hydroquinone first, then Licorice Extract. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Hydroquinone in the morning or at night?
Hydroquinone: best at night. Use only under a dermatologist's guidance, typically nightly on the dark patches for up to 3 months, then take a break. Strict daily sunscreen is required or results reverse.
Should I use Licorice Extract in the morning or at night?
Licorice Extract: works morning or night. Use once or twice daily. It pairs well with niacinamide, arbutin or vitamin C for dark spots.
Is Hydroquinone with Licorice Extract safe during pregnancy?
Hydroquinone is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.