How to use them
Use them in the same routine morning or night. Apply Niacinamide first, then PDRN, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2Niacinamide2% – 10%, wait about 1 minute
- 3PDRNvaries (often with PN/polynucleotides blends)
- 4Moisturiserseal everything in
What Niacinamide does
An all-rounder that controls oil, strengthens the skin barrier, reduces redness and evens out tone. It gets along with almost every other active, which is why it is in so many routines.
- Typical strength
- 2% – 10%
- When
- AM/PM
- Irritation
- Best for
- Oily, Combination, Normal, Sensitive And Dry skin
Everything that pairs with Niacinamide →
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
Frequently asked questions
Can I use Niacinamide and PDRN together?
Yes, it is safe. No known conflict. Niacinamide's barrier and tone benefits and PDRN's hydration claims are commonly layered together in Korean-style routines.
Which goes first, Niacinamide or PDRN?
Apply Niacinamide first, then PDRN. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Niacinamide in the morning or at night?
Niacinamide: works morning or night. Use morning, night or both, after water-based serums. 4–5% is enough for most people. Very high percentages can cause flushing on sensitive skin.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Is Niacinamide with PDRN safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN. Check with your doctor.