How to use them
Use them in the same routine at night. Apply Peptides first, then Tretinoin, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2Peptidesvaries, wait about 1 minute
- 3Tretinoin0.025% – 0.1% (prescription)
- 4Moisturiserseal everything in
What Peptides does
Short chains of amino acids that signal skin to support collagen and repair. They are gentle, a good anti-ageing option for people who cannot tolerate retinoids, and they layer easily.
- Typical strength
- varies
- When
- AM/PM
- Irritation
- Best for
- Dry, Normal, Sensitive And Combination skin
Everything that pairs with Peptides →
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
Trying to choose one? Read Peptides vs Tretinoin: which is better for your skin.
Frequently asked questions
Can I use Peptides and Tretinoin together?
Yes, it is safe. There is no known chemical conflict between Peptides and Tretinoin, and neither makes the other less effective. They share a goal (aging), so together they reinforce each other.
Which goes first, Peptides or Tretinoin?
Apply Peptides first, then Tretinoin. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Peptides in the morning or at night?
Peptides: works morning or night. Use morning and night after water-based serums. Low-pH acids applied at the same time can break some peptides down.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Is Peptides with Tretinoin safe during pregnancy?
Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.