How to use them
Use them in the same routine at night. Apply Adapalene first, then Urea, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2Adapalene0.1%, wait about 1 minute
- 3Urea5% – 10% (face), up to 40% (feet)
- 4Moisturiserseal everything in
What Adapalene does
A synthetic retinoid built for acne. It unclogs pores and calms the inflammation behind breakouts. It is more stable than retinol, and in India it is sold as a gel (often by prescription).
- Typical strength
- 0.1%
- When
- PM
- Irritation
- Best for
- Oily And Combination skin
Everything that pairs with Adapalene →
What Urea does
A natural moisturising factor that pulls water into skin. At 10% and above it also softens rough, flaky patches. It is excellent for very dry skin, keratosis pilaris and cracked heels.
- Typical strength
- 5% – 10% (face), up to 40% (feet)
- When
- AM/PM
- Irritation
- Best for
- Dry, Normal And Sensitive skin
Everything that pairs with Urea →
Trying to choose one? Read Adapalene vs Urea: which is better for your skin.
Frequently asked questions
Can I use Adapalene and Urea together?
Yes, and they work even better together. Urea cushions Adapalene: it hydrates and supports the barrier while the active does its work. That means less irritation and better results.
Which goes first, Adapalene or Urea?
Apply Adapalene first, then Urea. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Adapalene in the morning or at night?
Adapalene: best at night. Apply a thin layer to the whole acne-prone area at night, not just on spots. Expect a purge for 4–6 weeks. Use a moisturiser and daily SPF.
Should I use Urea in the morning or at night?
Urea: works morning or night. Use 5–10% on the face or body daily. Higher strengths can sting on broken or freshly exfoliated skin.
Is Adapalene with Urea safe during pregnancy?
Adapalene is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.