How to use them
Use them in the same routine morning or night. Apply Glutathione first, then PDRN, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2Glutathione1% – 2%, wait about 1 minute
- 3PDRNvaries (often with PN/polynucleotides blends)
- 4Moisturiserseal everything in
What Glutathione does
A popular "glow" antioxidant in India. Topically it has some evidence for mild brightening, but it is a large, unstable molecule. Expect modest results compared with vitamin C, arbutin or niacinamide.
- Typical strength
- 1% – 2%
- When
- AM/PM
- Irritation
- Best for
- Normal, Oily, Combination, Dry And Sensitive skin
Everything that pairs with Glutathione →
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
Frequently asked questions
Can I use Glutathione and PDRN together?
Yes, it is safe. There is no known chemical conflict between Glutathione and PDRN, and neither makes the other less effective.
Which goes first, Glutathione or PDRN?
Apply Glutathione first, then PDRN. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Glutathione in the morning or at night?
Glutathione: works morning or night. Use daily as part of a brightening routine, always with sunscreen. Glutathione injections and drips for skin whitening are not approved for that use and carry real risks.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Is Glutathione with PDRN safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for Glutathione and PDRN. Check with your doctor.