How to use them
Choose one retinoid and use it 2–4 nights a week. Fill the other nights with hydrating and barrier-repair products.
- 1CleanseGentle cleanser, pat dry
- AMAdapalene (day 1)then moisturiser and SPF 50
- PMTretinoin (day 2)then moisturiser
What Adapalene does
A synthetic retinoid built for acne. It unclogs pores and calms the inflammation behind breakouts. It is more stable than retinol, and in India it is sold as a gel (often by prescription).
- Typical strength
- 0.1%
- When
- PM
- Irritation
- Best for
- Oily And Combination skin
Everything that pairs with Adapalene →
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
Trying to choose one? Read Adapalene vs Tretinoin: which is better for your skin.
Frequently asked questions
Can I use Adapalene and Tretinoin together?
No, keep them apart. Adapalene and Tretinoin are both retinoids. Doubling up does not double results. It just doubles the dryness, peeling and irritation. Pick one.
Which goes first, Adapalene or Tretinoin?
Apply Adapalene first, then Tretinoin. The general rule is thinnest to thickest texture, and lowest pH first. For this pair, though, it is better not to layer them in the same routine at all.
Should I use Adapalene in the morning or at night?
Adapalene: best at night. Apply a thin layer to the whole acne-prone area at night, not just on spots. Expect a purge for 4–6 weeks. Use a moisturiser and daily SPF.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Is Adapalene with Tretinoin safe during pregnancy?
Adapalene and Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.