How to use them
Use them in the same routine at night. Apply Copper Peptides first, then PDRN, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2Copper Peptides0.1% – 1%, wait about 1 minute
- 3PDRNvaries (often with PN/polynucleotides blends)
- 4Moisturiserseal everything in
What Copper Peptides does
A peptide bound to copper that supports wound-healing, firmness and barrier repair. Copper is reactive, so it does not play well with strong acids or pure vitamin C.
- Typical strength
- 0.1% – 1%
- When
- PM
- Irritation
- Best for
- Normal, Dry And Combination skin
Everything that pairs with Copper Peptides →
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
Trying to choose one? Read Copper Peptides vs PDRN: which is better for your skin.
Frequently asked questions
Can I use Copper Peptides and PDRN together?
Yes, it is safe. There is no known chemical conflict between Copper Peptides and PDRN, and neither makes the other less effective. They share a goal (aging and barrier), so together they reinforce each other.
Which goes first, Copper Peptides or PDRN?
Apply Copper Peptides first, then PDRN. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Copper Peptides in the morning or at night?
Copper Peptides: best at night. Use at night on nights without acids or vitamin C. A thin layer is enough.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Is Copper Peptides with PDRN safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for Copper Peptides and PDRN. Check with your doctor.