How to use them
Alternate nights, for example Exosomes on Monday, Wednesday and Friday and Mandelic Acid on Tuesday and Thursday, with a plain moisturiser night in between if your skin feels sensitive. If your skin is resilient and already used to both, you can try layering them: apply Mandelic Acid first, wait a few minutes, then apply Exosomes.
- 1CleanseGentle cleanser, pat dry
- AMMandelic Acid (day 1)then moisturiser and SPF 50
- PMExosomes (day 2)then moisturiser
What Exosomes does
Tiny cell-signalling particles, most often derived from plant or stem-cell cultures for cosmetic use. In-clinic exosome treatments (injected or applied after microneedling) have more published evidence than the topical serums sold direct to consumers. Regulatory status varies by country, and topical evidence is still described as early and limited, so treat "regeneration" or anti-ageing claims with caution.
- Typical strength
- varies (plant- or stem-cell-derived)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Combination And Sensitive skin
Everything that pairs with Exosomes →
What Mandelic Acid does
The largest, slowest AHA. Dermatologists often pick it for melanin-rich Indian skin tones because it treats acne and pigmentation with a lower risk of post-inflammatory darkening.
- Typical strength
- 5% – 10%
- When
- PM
- Irritation
- Best for
- Sensitive, Oily And Combination skin
Everything that pairs with Mandelic Acid →
Trying to choose one? Read Exosomes vs Mandelic Acid: which is better for your skin.
Frequently asked questions
Can I use Exosomes and Mandelic Acid together?
Yes, but not at the same time. Low-pH acids can break down peptides, and with copper they can also irritate. Use the acid at one time of day and the peptide at the other, or on alternate nights.
Which goes first, Exosomes or Mandelic Acid?
Apply Mandelic Acid first, then Exosomes. The general rule is thinnest to thickest texture, and lowest pH first. For this pair, though, it is better not to layer them in the same routine at all.
Should I use Exosomes in the morning or at night?
Exosomes: works morning or night. If using a topical exosome serum, apply after cleansing and before heavier creams. For in-clinic exosome treatments, use only a qualified, licensed practitioner and ask what the exosomes are derived from.
Should I use Mandelic Acid in the morning or at night?
Mandelic Acid: best at night. Use 3–4 nights a week. It is mild enough that many people can use it more often than other acids.
Is Exosomes with Mandelic Acid safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for Exosomes. Check with your doctor.