How to use them
Use them in the same routine at night. Apply Tretinoin first, then Urea, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2Tretinoin0.025% – 0.1% (prescription), wait about 1 minute
- 3Urea5% – 10% (face), up to 40% (feet)
- 4Moisturiserseal everything in
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
What Urea does
A natural moisturising factor that pulls water into skin. At 10% and above it also softens rough, flaky patches. It is excellent for very dry skin, keratosis pilaris and cracked heels.
- Typical strength
- 5% – 10% (face), up to 40% (feet)
- When
- AM/PM
- Irritation
- Best for
- Dry, Normal And Sensitive skin
Everything that pairs with Urea →
Trying to choose one? Read Tretinoin vs Urea: which is better for your skin.
Frequently asked questions
Can I use Tretinoin and Urea together?
Yes, and they work even better together. Urea cushions Tretinoin: it hydrates and supports the barrier while the active does its work. That means less irritation and better results.
Which goes first, Tretinoin or Urea?
Apply Tretinoin first, then Urea. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Should I use Urea in the morning or at night?
Urea: works morning or night. Use 5–10% on the face or body daily. Higher strengths can sting on broken or freshly exfoliated skin.
Is Tretinoin with Urea safe during pregnancy?
Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.