How to use them
Split them up: use Vitamin C in your morning routine (under sunscreen) and Tretinoin at night.
- 1CleanseGentle cleanser, pat dry
- AMVitamin Cthen moisturiser and SPF 50
- PMTretinointhen moisturiser
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
What Vitamin C does
A powerful antioxidant that brightens dull skin, fades dark spots and boosts your sunscreen's protection against free radicals. Pure L-ascorbic acid works best at a low pH and oxidises (turns orange) quickly.
- Typical strength
- 10% – 20%
- When
- AM
- Irritation
- Best for
- Normal, Oily, Combination And Dry skin
Everything that pairs with Vitamin C →
Trying to choose one? Read Tretinoin vs Vitamin C: which is better for your skin.
Frequently asked questions
Can I use Tretinoin and Vitamin C together?
Yes, but not at the same time. These do not cancel each other out, but both can irritate, and they work best at different pH levels. The easy fix is vitamin C in the morning (where its antioxidant protection matters most) and the retinoid at night.
Which goes first, Tretinoin or Vitamin C?
Apply Vitamin C first, then Tretinoin. The general rule is thinnest to thickest texture, and lowest pH first. For this pair, though, it is better not to layer them in the same routine at all.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Should I use Vitamin C in the morning or at night?
Vitamin C: best in the morning. Apply in the morning on clean skin before moisturiser and sunscreen. Store it away from light and heat, and throw it out once it turns dark orange.
Is Tretinoin with Vitamin C safe during pregnancy?
Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.