How to use them
Use them in the same routine at night. Apply Tretinoin first, then Vitamin E, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2Tretinoin0.025% – 0.1% (prescription), wait about 1 minute
- 3Vitamin E0.5% – 1%
- 4Moisturiserseal everything in
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
What Vitamin E does
An oil-soluble antioxidant that protects skin lipids from damage and noticeably stabilises vitamin C. It is heavy in pure form, so it is better inside formulas than straight from a capsule.
- Typical strength
- 0.5% – 1%
- When
- AM/PM
- Irritation
- Best for
- Dry, Normal And Sensitive skin
Everything that pairs with Vitamin E →
Frequently asked questions
Can I use Tretinoin and Vitamin E together?
Yes, it is safe. There is no known chemical conflict between Tretinoin and Vitamin E, and neither makes the other less effective.
Which goes first, Tretinoin or Vitamin E?
Apply Tretinoin first, then Vitamin E. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Should I use Vitamin E in the morning or at night?
Vitamin E: works morning or night. Look for it combined with vitamin C and ferulic acid. Very oily or acne-prone skin should avoid pure vitamin E oil.
Is Tretinoin with Vitamin E safe during pregnancy?
Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.