How to use them
Use them in the same routine at night. Apply Zinc PCA first, then Tretinoin, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2Zinc PCA1%, wait about 1 minute
- 3Tretinoin0.025% – 0.1% (prescription)
- 4Moisturiserseal everything in
What Tretinoin does
The prescription-strength retinoid, and the gold standard for acne and photo-ageing, with decades of evidence. It works directly (no conversion needed), so it is stronger and more irritating than retinol or retinal.
- Typical strength
- 0.025% – 0.1% (prescription)
- When
- PM
- Irritation
- Best for
- Oily, Normal And Combination skin
Everything that pairs with Tretinoin →
What Zinc PCA does
Zinc salts help regulate sebum and have mild anti-inflammatory and antibacterial effects. That is why zinc so often appears next to niacinamide in oil-control serums.
- Typical strength
- 1%
- When
- AM/PM
- Irritation
- Best for
- Oily And Combination skin
Everything that pairs with Zinc PCA →
Trying to choose one? Read Tretinoin vs Zinc PCA: which is better for your skin.
Frequently asked questions
Can I use Tretinoin and Zinc PCA together?
Yes, it is safe. There is no known chemical conflict between Tretinoin and Zinc PCA, and neither makes the other less effective. They share a goal (acne), so together they reinforce each other.
Which goes first, Tretinoin or Zinc PCA?
Apply Zinc PCA first, then Tretinoin. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Tretinoin in the morning or at night?
Tretinoin: best at night. Use only as prescribed: a pea-sized amount on completely dry skin at night, starting 2–3 nights a week. Expect dryness and a possible purge for 4–8 weeks. Daily SPF is essential.
Should I use Zinc PCA in the morning or at night?
Zinc PCA: works morning or night. Use once or twice daily. It works best as part of a niacinamide or oil-control serum.
Is Tretinoin with Zinc PCA safe during pregnancy?
Tretinoin is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.