How to use them
Use them in the same routine morning or night. Apply Exosomes first, then PDRN, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2Exosomesvaries (plant- or stem-cell-derived), wait about 1 minute
- 3PDRNvaries (often with PN/polynucleotides blends)
- 4Moisturiserseal everything in
What Exosomes does
Tiny cell-signalling particles, most often derived from plant or stem-cell cultures for cosmetic use. In-clinic exosome treatments (injected or applied after microneedling) have more published evidence than the topical serums sold direct to consumers. Regulatory status varies by country, and topical evidence is still described as early and limited, so treat "regeneration" or anti-ageing claims with caution.
- Typical strength
- varies (plant- or stem-cell-derived)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Combination And Sensitive skin
Everything that pairs with Exosomes →
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
Trying to choose one? Read Exosomes vs PDRN: which is better for your skin.
Frequently asked questions
Can I use Exosomes and PDRN together?
Yes, it is safe. There is no known chemical conflict between Exosomes and PDRN, and neither makes the other less effective. They share a goal (aging and barrier), so together they reinforce each other.
Which goes first, Exosomes or PDRN?
Apply Exosomes first, then PDRN. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use Exosomes in the morning or at night?
Exosomes: works morning or night. If using a topical exosome serum, apply after cleansing and before heavier creams. For in-clinic exosome treatments, use only a qualified, licensed practitioner and ask what the exosomes are derived from.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Is Exosomes with PDRN safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for Exosomes and PDRN. Check with your doctor.