How to use them
Use them in the same routine morning or night. Apply PDRN first, then Peptides, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2PDRNvaries (often with PN/polynucleotides blends), wait about 1 minute
- 3Peptidesvaries
- 4Moisturiserseal everything in
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
What Peptides does
Short chains of amino acids that signal skin to support collagen and repair. They are gentle, a good anti-ageing option for people who cannot tolerate retinoids, and they layer easily.
- Typical strength
- varies
- When
- AM/PM
- Irritation
- Best for
- Dry, Normal, Sensitive And Combination skin
Everything that pairs with Peptides →
Trying to choose one? Read PDRN vs Peptides: which is better for your skin.
Frequently asked questions
Can I use PDRN and Peptides together?
Yes, it is safe. There is no known chemical conflict between PDRN and Peptides, and neither makes the other less effective. They share a goal (aging, barrier and hydration), so together they reinforce each other.
Which goes first, PDRN or Peptides?
Apply PDRN first, then Peptides. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Should I use Peptides in the morning or at night?
Peptides: works morning or night. Use morning and night after water-based serums. Low-pH acids applied at the same time can break some peptides down.
Is PDRN with Peptides safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN. Check with your doctor.