How to use them
Use them in the same routine at night. Apply PDRN first, then Retinol, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2PDRNvaries (often with PN/polynucleotides blends), wait about 1 minute
- 3Retinol0.1% – 1%
- 4Moisturiserseal everything in
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
What Retinol does
The most studied over-the-counter anti-ageing active. Retinol speeds up cell turnover, softens fine lines, fades marks and keeps pores clear, but it can cause dryness, peeling and sun sensitivity while your skin adjusts.
- Typical strength
- 0.1% – 1%
- When
- PM
- Irritation
- Best for
- Normal, Oily And Combination skin
Everything that pairs with Retinol →
Trying to choose one? Read PDRN vs Retinol: which is better for your skin.
Frequently asked questions
Can I use PDRN and Retinol together?
Yes, it is safe. There is no known chemical conflict between PDRN and Retinol, and neither makes the other less effective. They share a goal (aging), so together they reinforce each other.
Which goes first, PDRN or Retinol?
Apply PDRN first, then Retinol. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Should I use Retinol in the morning or at night?
Retinol: best at night. Start 2–3 nights a week on dry skin, a pea-sized amount for the whole face, then build up. Always wear sunscreen the next morning.
Is PDRN with Retinol safe during pregnancy?
Retinol is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.