How to use them
Use them in the same routine in the morning. Apply Vitamin C first, then PDRN, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2Vitamin C10% – 20%, wait about 1 minute
- 3PDRNvaries (often with PN/polynucleotides blends)
- 4Moisturiserthen SPF 50 in the morning
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
What Vitamin C does
A powerful antioxidant that brightens dull skin, fades dark spots and boosts your sunscreen's protection against free radicals. Pure L-ascorbic acid works best at a low pH and oxidises (turns orange) quickly.
- Typical strength
- 10% – 20%
- When
- AM
- Irritation
- Best for
- Normal, Oily, Combination And Dry skin
Everything that pairs with Vitamin C →
Trying to choose one? Read PDRN vs Vitamin C: which is better for your skin.
Frequently asked questions
Can I use PDRN and Vitamin C together?
Yes, it is safe. There is no known chemical conflict. Vitamin C's antioxidant, brightening effect and PDRN's hydration/repair claims target different things, so some brands sell them as a combined "glass skin" step. Evidence for the topical PDRN side of this pairing is still early, so treat dramatic before/afters with caution.
Which goes first, PDRN or Vitamin C?
Apply Vitamin C first, then PDRN. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Should I use Vitamin C in the morning or at night?
Vitamin C: best in the morning. Apply in the morning on clean skin before moisturiser and sunscreen. Store it away from light and heat, and throw it out once it turns dark orange.
Is PDRN with Vitamin C safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN. Check with your doctor.