How to use them
Alternate nights, for example PDRN on Monday, Wednesday and Friday and Salicylic Acid on Tuesday and Thursday, with a plain moisturiser night in between if your skin feels sensitive. If your skin is resilient and already used to both, you can try layering them: apply Salicylic Acid first, wait a few minutes, then apply PDRN.
- 1CleanseGentle cleanser, pat dry
- AMSalicylic Acid (day 1)then moisturiser and SPF 50
- PMPDRN (day 2)then moisturiser
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
What Salicylic Acid does
An oil-soluble beta-hydroxy acid that gets inside pores to dissolve the sebum and dead skin behind blackheads, whiteheads and breakouts. It is the go-to for oily, acne-prone skin.
- Typical strength
- 0.5% – 2%
- When
- AM/PM
- Irritation
- Best for
- Oily And Combination skin
Everything that pairs with Salicylic Acid →
Frequently asked questions
Can I use PDRN and Salicylic Acid together?
Yes, but not at the same time. Low-pH acids can break down peptides, and with copper they can also irritate. Use the acid at one time of day and the peptide at the other, or on alternate nights.
Which goes first, PDRN or Salicylic Acid?
Apply Salicylic Acid first, then PDRN. The general rule is thinnest to thickest texture, and lowest pH first. For this pair, though, it is better not to layer them in the same routine at all.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Should I use Salicylic Acid in the morning or at night?
Salicylic Acid: works morning or night. Use as a cleanser daily or a leave-on 2% serum 3–4 times a week. It can dry out skin, so moisturise well.
Is PDRN with Salicylic Acid safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN and Salicylic Acid. Check with your doctor.