How to use them
Use them in the same routine morning or night. Apply Polyglutamic Acid first, then PDRN, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2Polyglutamic Acid1% – 3%, wait about 1 minute
- 3PDRNvaries (often with PN/polynucleotides blends)
- 4Moisturiserseal everything in
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
What Polyglutamic Acid does
A bigger-molecule humectant that forms a moisture-holding film on the skin. It is often paired with hyaluronic acid for plump, long-lasting hydration.
- Typical strength
- 1% – 3%
- When
- AM/PM
- Irritation
- Best for
- Dry, Normal, Combination, Sensitive And Oily skin
Everything that pairs with Polyglutamic Acid →
Frequently asked questions
Can I use PDRN and Polyglutamic Acid together?
Yes, it is safe. There is no known chemical conflict between PDRN and Polyglutamic Acid, and neither makes the other less effective. They share a goal (barrier and hydration), so together they reinforce each other.
Which goes first, PDRN or Polyglutamic Acid?
Apply Polyglutamic Acid first, then PDRN. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Should I use Polyglutamic Acid in the morning or at night?
Polyglutamic Acid: works morning or night. Apply after toner and before moisturiser, morning or night.
Is PDRN with Polyglutamic Acid safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN. Check with your doctor.