How to use them
Use them in the same routine at night. Apply PDRN first, then Retinal, moving from thinnest to thickest texture.
- 1CleanseGentle cleanser, pat dry
- 2PDRNvaries (often with PN/polynucleotides blends), wait about 1 minute
- 3Retinal0.05% – 0.2%
- 4Moisturiserseal everything in
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
What Retinal does
Retinaldehyde is one conversion step closer to retinoic acid than retinol, so it works faster than retinol while usually being gentler than tretinoin. It also has a mild antibacterial effect useful for acne.
- Typical strength
- 0.05% – 0.2%
- When
- PM
- Irritation
- Best for
- Normal, Oily, Combination And Dry skin
Everything that pairs with Retinal →
Trying to choose one? Read PDRN vs Retinal: which is better for your skin.
Frequently asked questions
Can I use PDRN and Retinal together?
Yes, it is safe. No known conflict. Retinal is the stronger, more irritating one, and PDRN is a gentle hydrating step, so it is a sensible partner on retinal nights. The evidence for topical PDRN is still thin (see our PDRN guide), so do not count on it to offset irritation.
Which goes first, PDRN or Retinal?
Apply PDRN first, then Retinal. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Should I use Retinal in the morning or at night?
Retinal: best at night. Start at 0.05% two or three nights a week and build up slowly. Buffer with moisturiser if you are sensitive, and wear SPF daily.
Is PDRN with Retinal safe during pregnancy?
Retinal is generally avoided during pregnancy and breastfeeding. Ask your doctor about safer alternatives such as azelaic acid or bakuchiol.