How to use them
Use them in the same routine morning or night. Apply PDRN first, then Squalane, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2PDRNvaries (often with PN/polynucleotides blends), wait about 1 minute
- 3Squalaneup to 100%
- 4Moisturiserseal everything in
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
What Squalane does
A lightweight, stable oil that mimics your skin's own sebum. It softens and seals in moisture without clogging pores, so even oily skin usually tolerates it.
- Typical strength
- up to 100%
- When
- AM/PM
- Irritation
- Best for
- Dry, Normal, Combination, Sensitive And Oily skin
Everything that pairs with Squalane →
Frequently asked questions
Can I use PDRN and Squalane together?
Yes, it is safe. There is no known chemical conflict between PDRN and Squalane, and neither makes the other less effective. They share a goal (barrier and hydration), so together they reinforce each other.
Which goes first, PDRN or Squalane?
Apply PDRN first, then Squalane. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Should I use Squalane in the morning or at night?
Squalane: works morning or night. Press 2–3 drops in as the last step at night, or mix a drop into your moisturiser.
Is PDRN with Squalane safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN. Check with your doctor.