How to use them
Use them in the same routine morning or night. Apply PDRN first, then Sulfur, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2PDRNvaries (often with PN/polynucleotides blends), wait about 1 minute
- 3Sulfur3% – 10%
- 4Moisturiserseal everything in
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
What Sulfur does
An old-school acne fighter that dries out oily spots, gently exfoliates and has antibacterial and antifungal activity. It is gentler than benzoyl peroxide for many people, though it has a distinctive smell.
- Typical strength
- 3% – 10%
- When
- AM/PM
- Irritation
- Best for
- Oily, Combination And Sensitive skin
Everything that pairs with Sulfur →
Frequently asked questions
Can I use PDRN and Sulfur together?
Yes, it is safe. There is no known chemical conflict between PDRN and Sulfur, and neither makes the other less effective.
Which goes first, PDRN or Sulfur?
Apply PDRN first, then Sulfur. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Should I use Sulfur in the morning or at night?
Sulfur: works morning or night. Use as a spot treatment, a clay mask or a short-contact wash. It can be drying, so moisturise afterwards.
Is PDRN with Sulfur safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN and Sulfur. Check with your doctor.