How to use them
Use them in the same routine morning or night. Apply Tranexamic Acid first, then PDRN, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2Tranexamic Acid2% – 5%, wait about 1 minute
- 3PDRNvaries (often with PN/polynucleotides blends)
- 4Moisturiserseal everything in
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
What Tranexamic Acid does
A gentle brightener that interrupts the signals behind melasma, sun spots and post-acne marks, without the irritation of hydroquinone or strong acids.
- Typical strength
- 2% – 5%
- When
- AM/PM
- Irritation
- Best for
- Sensitive, Normal, Oily, Combination And Dry skin
Everything that pairs with Tranexamic Acid →
Frequently asked questions
Can I use PDRN and Tranexamic Acid together?
Yes, it is safe. There is no known chemical conflict between PDRN and Tranexamic Acid, and neither makes the other less effective.
Which goes first, PDRN or Tranexamic Acid?
Apply Tranexamic Acid first, then PDRN. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Should I use Tranexamic Acid in the morning or at night?
Tranexamic Acid: works morning or night. Use once or twice daily for at least 8–12 weeks. It works best alongside a daily broad-spectrum sunscreen.
Is PDRN with Tranexamic Acid safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN and Tranexamic Acid. Check with your doctor.