How to use them
Use them in the same routine morning or night. Apply PDRN first, then Urea, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2PDRNvaries (often with PN/polynucleotides blends), wait about 1 minute
- 3Urea5% – 10% (face), up to 40% (feet)
- 4Moisturiserseal everything in
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
What Urea does
A natural moisturising factor that pulls water into skin. At 10% and above it also softens rough, flaky patches. It is excellent for very dry skin, keratosis pilaris and cracked heels.
- Typical strength
- 5% – 10% (face), up to 40% (feet)
- When
- AM/PM
- Irritation
- Best for
- Dry, Normal And Sensitive skin
Everything that pairs with Urea →
Frequently asked questions
Can I use PDRN and Urea together?
Yes, it is safe. There is no known chemical conflict between PDRN and Urea, and neither makes the other less effective. They share a goal (barrier and hydration), so together they reinforce each other.
Which goes first, PDRN or Urea?
Apply PDRN first, then Urea. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Should I use Urea in the morning or at night?
Urea: works morning or night. Use 5–10% on the face or body daily. Higher strengths can sting on broken or freshly exfoliated skin.
Is PDRN with Urea safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN. Check with your doctor.