How to use them
Use them in the same routine morning or night. Apply Zinc PCA first, then PDRN, moving from thinnest to thickest texture. Finish with sunscreen in the morning.
- 1CleanseGentle cleanser, pat dry
- 2Zinc PCA1%, wait about 1 minute
- 3PDRNvaries (often with PN/polynucleotides blends)
- 4Moisturiserseal everything in
What PDRN does
Polydeoxyribonucleotide, a salmon-DNA-derived ingredient best known from in-clinic "salmon DNA" injections and now sold in serums. Early clinical studies suggest it may support tissue repair and hydration, but topical (as opposed to injected) evidence is still limited, so treat claims of dramatic results with caution.
- Typical strength
- varies (often with PN/polynucleotides blends)
- When
- AM/PM
- Irritation
- Best for
- Normal, Dry, Sensitive And Combination skin
Everything that pairs with PDRN →
What Zinc PCA does
Zinc salts help regulate sebum and have mild anti-inflammatory and antibacterial effects. That is why zinc so often appears next to niacinamide in oil-control serums.
- Typical strength
- 1%
- When
- AM/PM
- Irritation
- Best for
- Oily And Combination skin
Everything that pairs with Zinc PCA →
Frequently asked questions
Can I use PDRN and Zinc PCA together?
Yes, it is safe. There is no known chemical conflict between PDRN and Zinc PCA, and neither makes the other less effective.
Which goes first, PDRN or Zinc PCA?
Apply Zinc PCA first, then PDRN. The general rule is thinnest to thickest texture, and lowest pH first.
Should I use PDRN in the morning or at night?
PDRN: works morning or night. Use as a serum step, morning or night. It has no known irritancy, so it layers easily with most other actives. It is not a substitute for an in-clinic PDRN treatment, which uses injectable-grade material under medical supervision.
Should I use Zinc PCA in the morning or at night?
Zinc PCA: works morning or night. Use once or twice daily. It works best as part of a niacinamide or oil-control serum.
Is PDRN with Zinc PCA safe during pregnancy?
Neither is a known risk in normal cosmetic amounts, but guidance varies for PDRN. Check with your doctor.